Model: improved-method R,R-oxaliplatin base (`c9pcp` scaffold). Dashed lines = heavy-atom H-bonds (donor N/O ··· acceptor O ≤ 3.5 Å; H not modelled). The damaged strand (chain B) is clamped in the channel by a cage of Arg/Lys/Ser/Thr/Tyr onto the phosphate backbone; His135 is the verification residue at the lesion.