My human XPD–oxaliplatin model superposed on the experimental
cyclobutane-dimer structure PDB 8REV (ctXPD stalled on a cross-linked duplex;
Kuper et al., Nat Struct Mol Biol 2024). Aligned on the protein (XPD↔ctXPD homologs),
so both lesions sit in the same verification pocket.
Oxaliplatin Pt-d(GpG) — my model (at His135)
Cyclobutane dimer L5R — experimental 8REV
human XPD (model)
ctXPD (8REV, experimental)
His135 verification residue
| oxaliplatin (model) | cyclobutane dimer (8REV) |
|---|
| lesion type | 1,2-d(GpG) intrastrand, Pt-crosslink | interstrand cyclobutane(ene) dimer (L5R) |
| → His135 | 4.1 Å (in pocket) | 13.1 Å (deeper register) |
| two-base angle | 24° destack | covalent cyclobutane ring |